Sunday, 6 January 2008

Just wondering

Have been staying in the library for three days now and because it is warmer in the library, i managed to make my brain absorb some of the essential stuff that we need to know in order to pass the dreaded .... *gasp*... exams..

Here's something i was wondering while revising on molecular pharmacology this afternoon. First, some basics. Nitric Oxide (NO.) is a gaseous radical and is extremely reactive, which causes the smooth muscles in our body to relax. NO. also causes penile erection.

Nitric Oxide is also abundant during a lightning storm. So.... Does that mean that men are getting erections everytime there is a lightning storm? lol.. but after thinking about it.. i guess not. Since NO. is so reactive.. it'll probably not reach there in time...

I deduced another thing when i was revising but don't think there's any point in blogging that as it'll only take someone who has learnt molecular pharmacology to get that. The wonders of molecular pharmacology. I quite like this module..


Well, decided to write down what i was thinking about anyway.. so if you're not interested don't continue reading...


cGMP is broken down by phosphodiesterase 5 (PDE5) to 5'-GMP. If there is an increase in cGMP, that means that there would be excess fluid that is secreted into the gut lumen, causing diarrhoea. Based on those two facts, that means that by applying a PDE5 inhibitor, we would inhibit the break down of cGMP and there would be an increase in cGMP, thereby causing diarrhoea, right? Sildenafil or better known as Viagra is a PDE5 inhibitor... But BNF doesn't say anything about diarrhoea as side effect. I'm just speculating.. don't take me too seriously.. the dose is probably too low to cause diarrhoea anyway..

really.. things i can link together while studying molecular pharmacology

5 comments:

Yan Leng said...

u like MP? u r siao la!!! i hate MP so so so so much now, stress level= maximum now...

~em~ said...

i just realise i cannot remember anything today.. lol.. hahaha...

Yan Leng said...

i cant remember everything too...u somemore can haha, lol? aih....reli siao d...

mrbherng said...

NO will be oxidise to NO2 extremely quickyly in the oxygen rich atmospheric enviroment.. so if the NO will ever get across the multiple layers of barrier in the body to reach the smooth muscles, I guess that person will literally 给雷劈 and should be toasted before any erecion will occurs.

and if one really have enough cGMP to cause diarrhoea.. I bet he will be dead than too worry about where's the nearest loo. eg. die from convulsion?? or any other metabolic illnesses???

Anyway, enjoy pharmacology. It is definitely much easier than trying to memorise one whole pile of dry facts.

~em~ said...

ahhaha... nah.. won't die before having diarrhoea.. same effect as bacterial toxins.. haha...

well.. no more interesting molpharm... on to nutrition next.. which is all hard facts.